VCP acts through UBX- domain- containing adaptors that provide target specificity, but the targets and functions of UBXD proteins remain poorly understood. Through systematic proteomic analysis of UBXD proteins in human cells reported in Nature Cell Biology, the Harper lab revealed a network of over 1. VCP in diverse cellular pathways based on Gene Ontology analysis. Through detailed analysis of the interaction partners for the unstudied adaptor UBXN1. VCP/p. 97 in ciliogenesis. Using TIRF microscopy in living cells, the demonstrate that UBXN1. IFT- B complex. Moreover, deletion of UBXN1. Harvard Medical School; Established: 1966: Chairman. The Department is part of the Basic Research Program at Harvard Medical School. 1.04 Student Assessment in the MD Program. 1.05 Five-Year MD Program. 1.06 Five-Year MD Program. 1.00 The Learning Environment at Harvard Medical School; 1.01 Plan of Instruction. Pharmacological inhibition of VCP destabilized they IFT- B complex and increased trafficking rates. Depletion of UBXN1. This study provides a resource for exploring the landscape of UBXD proteins in biology and identifies an unexpected requirement for VCP–UBXN1. Raman, M, Sergeev, M, Garnaas M, Lydeard JR, Huttlin EL, Goessling W, Shah JV, and Harper JW.
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